University of Pittsburgh
PUBLICATIONS
HBowman RW, Jordahl EM, Davis S, Hedayati S, Barsouk H, Ozbaki-Yagan N, Chiang A, Li Y, and O'Donnell AF. (2022) Biomolecules 2022 Mar 31;12(4)
Hellemann E, Walker JL, Lesko MA, Charandrashekarappa DG, Schmidt MC, O'Donnell A.F., Durrant, JD. (2022) Novel mutations in hexokinase 2 confers resistance to 2-deoxyglucose by altering protein dynamics. PLoS Comput Biol. 2022 Mar 2;18(3)
Hager NA, McAtee CK, Lesko MA and O’Donnell AF (2022) Inwardly Rectifying Potassium Channel Kir2.1 and its “Kir-ious” Regulation by Protein Trafficking and Roles in Development and Disease. Front. Cell Dev. Biol. 9:796136. doi: 10.3389/fcell.2021.796136
Robinson, B.P., Hawbaker, S., Chiang, A., Jordahl, E.M., Anaokar, S., Nikiforov, A., Bowman II, R.W., Ziegler, P., McAtee, C.K., Patton-Vogt, J. & O'Donnell, A.F. (2021) Alpha-arrestins Aly1 and Aly2 regulate trafficking of the glycerophosphoinositol transporter Git1 and impact phospholipid homeostasis. Biology of the Cell, 114, 3-31. https://doi.org/10.1111/boc.202100007
Schmidt M.C. and O'Donnell A.F. (2020) 'Sugarcoating' 2-deoxyglucose: mechanisms that suppress its toxic effects. Curr Genet. 2021 Fab;67(1):107-114. doi: 10.1007/s.00294-020-01122-7
Soncini S.R., Chandrashekarappa D.G., Augustine D.A., Callahan K.P., O'Donnell A.F., Schmidt M.C. (2020) Spontaneous mutations that confer resistance to 2-deoxyglucose act through Hxk2 and Snf1 pathways to regulate gene expression and HXT endocytosis. PLoS Genet. 2020 Jul 16;16(7)
Vakirlis N., Acar O., Hsu B., Castilho Coelho N., Van Oss S.B., Wacholder A., Medetgul-Ernar K., Bowman R.W. 2nd, Hines C.P., Iannotta J., Parikh S.B., McLysaght A., Camacho C.J., O'Donnell A.F., Ideker T., Carvunis A.R. (2020) De novo emergence of adaptive membrane protein from thymine-rich genomic sequences. Nat Commun. Feb 7;11(1):781
O'Donnell, A.F., Schmidt, M.C. (2019) Helping daughters succeed: asymmetric distribution of glucose transporter mRNA. EMBO J. 15;38(10)
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O'Donnell, A.F., Schmidt, M.C. (2019) AMPK-Mediated Regulation of Alpha-Arrestins and Protein Trafficking. Int J Mol Sci. 20(3)
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Hager, N.A., Kraswoski, C.J., Mackie, T.D., Kolb, A.R., Needham, P.G., Augustine, A.A., Dempsey, A., Szent-Gyorgyi, C., Bruchez, M.P., Bain, D.J., Kwiatkowski, A.V., O'Donnell, A.F., Brodsky, J.L. (2018) Select a-arrestins control cell-surface abundance of the mammalian Kir2.1 potassium channel in a yeast model. The Journal of Biological Chemistry. 293 (28):11006-11021.
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Mackie, T. D., Kim, B.Y., Subramanya A.R., Bain, D.J., O'Donnell A.F., Welling, P.A., Brodsky, J.L. (2018) The endosomal trafficking factors CORVET and ESCRT suppress plasma membrane residence of the renal outer medullary potassium channel (ROMK). The Journal of Biological Chemistry. 293(9):3201-3217
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Chandrashekarappa, D.G., R.R. McCartney, A.F. O'Donnell, and M.C. Schmidt. (2016) The β subunit of yeast AMP-activated protein kinase directs substrate specificity in response to alkaline stress. Cellular Signaling, S0898065568(16):302221-2.
Prosser, D.C., A.E. Pannunzio, J.L. Brodsky, J. Thorner, B. Wendland, and A.F. O'Donnell. (2015) α-Arrestins participate in cargo selection for both clathrin-independent and clathrin-mediated endocytosis. The Journal of Cell Science 128 (22): 4220-4234.
O'Donnell, A.F., R. R. McCartney, D. G. Chandrashekarappa, B. Zhang, J. Thorner, and M.C. Schmidt. (2014) 2-Deoxyglucose impairs yeast growth by stimulating Snf1-regulated and α-arrestin-mediated trafficking of hexose transporters 1 and 3 in Saccharomyces cerevisiae. Molecular and Cellular Biology, 35(6):939-55.
C.G. Alvaro, A.F. O'Donnell*, D.C. Prosser, A.A. Augustine, A. Goldman, J. Brodsky, M.S. Cyert, B. Wendland, and J. Thorner. (2014) Specific α-arrestins negatively regulate Saccharomyces cerevisiae pheromone response by down-modulating the G-protein coupled recpetor Ste2. Molecular and Cellular Biology 34(14):2660-81.
*Co-first author
Hecht, K.A., A.F. O'Donnell, and J. Brodsky. (2014) The proteolytic landscape of the yeast vacuole. Cellular Logistics 4(1): e28023.
O'Donnell, A.F., L. Huang, J. Thorner, and M.S. Cyert. (2013) A calcineurin-dependent switch controls the trafficking function of α-arrestin Aly1/Art6. The Journal of Biological Chemistry. 288 (33): 24063-24080
O'Donnell, A.F. (2012) The running of the Buls: Control of permease trafficking by α-arrestins Bul1 and Bul2. Molecular and Cellular Biology 32 (22): 4506-09.
Stevens, J.R., A.F. O'Donnell, T.E. Perry, J.R. Benjamin, C.A. Barnes, G.C. Johnston, and R.A. Singer. (2011) FACT, the Bur kinase pathway, and the histone co-repressor HirC have overlapping nucleosome-related roles in yeast transcription elongation. PLoS One 6 (10): e25644.
Minear, S., A.F. O'Donnell*, G. Giaever, C. Nislow, T. Stearns, and M.S. Cyert. (2011) Curcumin inhibits growth of Saccharomyces cerevisiae through iron chelation. Eukaryotic Cell 10 (11): 1574-81. *Co-first author
Piña, F.J., A.F. O'Donnell, S. Pagant, H.L. Piao, J.P. Miller, S. Fields, E.A. Miller, and M.S. Cyert. (2011) Hph1 and Hph2 are novel components of the Sec63/Sec62 posttranslational translocation complex that aid in vacuolar proton ATPase biogenesis. Eukaryotic Cell 10 (1): 63-71.
O'Donnell, A.F., A. Apffel, R.G. Gardner, and M.S. Cyert. (2010) α-arrestins Aly1 and Aly2 regulate intracellular trafficking in response to nutrient signaling. Molecular Biology of the Cell 21 (20): 3552-3566.
(Highlighted publication in MBoC)
O'Donnell, A.F., J.R. Stevens, R. Kepkay, C.A. Barnes, G.C. Johnston, and R.A. Singer. (2009) New mutant versions of yeast FACT subunit Spt16 affect cell integrity. Molecular Genetics and Genomics 282 (5): 487-502.
O'Donnell, A.F., N.K. Brewster, J. Kurniawan, L.V. Minard, G.C. Johnston, and R.A. Singer. (2004) Domain organization of the yeast histone chaperone FACT: the conserved N-terminal domain of FACT subunit Spt16 mediates recovery from replication stress. Nucleic Acids Research 32 (19): 5894-5906.
O'Donnell, A.F., S. Tiong, D. Nash, and D.V. Clark (2000) The Drosophila melanogaster ade5 gene encodes a bifunctional enzyme for two steps in the de novo purine synthesis pathway. Genetics 154 (3): 1239-1253.
