University of Pittsburgh
O'Donnell Lab Collaborators
Jeffrey Brodsky, PhD (University of Pittsburgh)
Position: Professor, Avinoff Chair of Biological Sciences
Area of Study: Protein quality control
Website: http://www.biology.pitt.edu/person/jeffrey-brodsky
Contact: jbrodsky@pitt.edu
Co-authored Papers:
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Hager, N.A., Kraswoski, C.J., Mackie, T.D., Kolb, A.R., Needham, P.G., Augustine, A.A., Dempsey, A., Szent-Gyorgyi, C., Bruchez, M.P., Bain, D.J., Kwiatkowski, A.V., O'Donnell, A.F., Brodsky, J.L. Select a-arrestins control cell-surface abundance of the mammalian Kir2.1 potassium channel in a yeast model. The Journal of Biological Chemistry. 293 (28):11006-11021.
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Mackie, T. D., Kim, B.Y., Subramanya A.R., Bain, D.J., O'Donnell A.F., Welling, P.A., Brodsky, J.L. The endosomal trafficking factors CORVET and ESCRT suppress plasma membrane residence of the renal outer medullary potassium channel (ROMK). The Journal of Biological Chemistry. 293(9):3201-3217
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Prosser, D.C., A.E. Pannunzio, J.L. Brodsky, J. Thorner, B. Wendland, and A.F. O'Donnell. (2015) α-Arrestins participate in cargo selection for both clathrin-independent and clathrin-mediated endocytosis. The Journal of Cell Science 128 (22): 4220-4234.
C.G. Alvaro, A.F. O'Donnell*, D.C. Prosser, A.A. Augustine, A. Goldman, J. Brodsky, M.S. Cyert, B. Wendland, and J. Thorner. (2014) Specific α-arrestins negatively regulate Saccharomyces cerevisiae pheromone response by down-modulating the G-protein coupled recpetor Ste2. Molecular and Cellular Biology 34(14):2660-81.
*Co-first author
Hecht, K.A., A.F. O'Donnell, and J. Brodsky. (2014) The proteolytic landscape of the yeast vacuole. Cellular Logistics 4(1): e28023.
Martin C. Schmidt, PhD (University of Pittsburgh)
Position: Associate Professor
Area of Study: Snf1 kinase of yeast
Website: http://www.mmg.pitt.edu/node/301
Contact: mcs2@pitt.edu
Co-authored Papers:
Schmidt M.C. and O'Donnell A.F. (2020) 'Sugarcoating' 2-deoxyglucose: mechanisms that suppress its toxic effects. Curr Genet. 2021 Fab;67(1):107-114. doi: 10.1007/s.00294-020-01122-7
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Soncini S.R., Chandrashekarappa D.G., Augustine D.A., Callahan K.P., O'Donnell A.F., Schmidt M.C. (2020) Spontaneous mutations that confer resistance to 2-deoxyglucose act through Hxk2 and Snf1 pathways to regulate gene expression and HXT endocytosis. PLoS Genet. 2020 Jul 16;16(7)
O'Donnell, A.F., Schmidt, M.C. (2019) Helping daughters succeed: asymmetric distribution of glucose transporter mRNA. EMBO J. 15;38(10)
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O'Donnell, A.F., Schmidt, M.C. (2019) AMPK-Mediated Regulation of Alpha-Arrestins and Protein Trafficking. Int J Mol Sci. 20(3)
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O'Donnell, A.F., R. R. McCartney, D. G. Chandrashekarappa, B. Zhang, J. Thorner, and M.C. Schmidt. (2014) 2-Deoxyglucose impairs yeast growth by stimulating Snf1-regulated and α-arrestin-mediated trafficking of hexose transporters 1 and 3 in Saccharomyces cerevisiae. Molecular and Cellular Biology, 35(6):939-55.
Nathan L. Clark, PhD (University of Pittsburgh)
Position: Assistant Professor
Area of Study: Molecular Evolution, Comparative Genomics
Website: https://www.csb.pitt.edu/faculty/clark/
Contact: nclark@pitt.edu
Michael Knop, PhD (University of Heidelberg)
Position: Professor
Area of Study: Regulation of cellular morphogenesis and cell signaling
Website: http://www.zmbh.uni-heidelberg.de/Knop/default.shtml
Contact: m.knop@zmbh.uni-heidelberg.de
Beverly Wendland, PhD (Johns Hopkins University)
Position: Professor, James B. Knapp Dean of the Krieger School of Arts & Sciences
Area of Study: Molecular mechanisms and regulation of endocytic vesicle formation
Website: http://bio.jhu.edu/directory/beverly-wendland/
Contact: bwendland@jhu.edu
Co-authored Papers:
Prosser, D. C., Wrasman, K., Woodard, T. K., O’Donnell, A. F., Wendland, B. (2016) Applications of pHluorin for Quantitative, Kinetic and High-throughput Analysis of Endocytosis in Budding Yeast. J. Vis. Exp. (116), e54587, doi:10.3791/54587.
Prosser, D.C., A.E. Pannunzio, J.L. Brodsky, J. Thorner, B. Wendland, and A.F. O'Donnell. (2015) α-Arrestins participate in cargo selection for both clathrin-independent and clathrin-mediated endocytosis. The Journal of Cell Science 128 (22): 4220-4234.
C.G. Alvaro, A.F. O'Donnell*, D.C. Prosser, A.A. Augustine, A. Goldman, J. Brodsky, M.S. Cyert, B. Wendland, and J. Thorner. (2014) Specific α-arrestins negatively regulate Saccharomyces cerevisiae pheromone response by down-modulating the G-protein coupled recpetor Ste2. Molecular and Cellular Biology 34(14):2660-81.
*Co-first author
Derek C. Prosser (Virginia Commonwealth University)
Position: Assistant Professor
Area of Study: Molecular mechanisms and regulation of endocytic vesicle formation
Website: http://johnshopkins.academia.edu/DerekProsser
Contact: dprosser@vcu.edu
Co-authored Papers:
Prosser, D. C., Wrasman, K., Woodard, T. K., O’Donnell, A. F., Wendland, B. (2016) Applications of pHluorin for Quantitative, Kinetic and High-throughput Analysis of Endocytosis in Budding Yeast. J. Vis. Exp. (116), e54587, doi:10.3791/54587.
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Prosser, D.C., A.E. Pannunzio, J.L. Brodsky, J. Thorner, B. Wendland, and A.F. O'Donnell. (2015) α-Arrestins participate in cargo selection for both clathrin-independent and clathrin-mediated endocytosis. The Journal of Cell Science 128 (22): 4220-4234.
C.G. Alvaro, A.F. O'Donnell*, D.C. Prosser, A.A. Augustine, A. Goldman, J. Brodsky, M.S. Cyert, B. Wendland, and J. Thorner. (2014) Specific α-arrestins negatively regulate Saccharomyces cerevisiae pheromone response by down-modulating the G-protein coupled recpetor Ste2. Molecular and Cellular Biology 34(14):2660-81.
*Co-first author
Marcel P. Bruchez, PhD (Carnegie Mellon University)
Position: Associate Professor, Director, Molecular Biosensors and Imaging Center
Area of Study: Development of tools for single molecule based super resolution microscopy, protein trafficking and sub-cellular physiology
Website: http://bruchez-lab.mbic.cmu.edu/research.php
Contact: bruchez@cmu.edu
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Co-authored Papers:
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Hager, N.A., Kraswoski, C.J., Mackie, T.D., Kolb, A.R., Needham, P.G., Augustine, A.A., Dempsey, A., Szent-Gyorgyi, C., Bruchez, M.P., Bain, D.J., Kwiatkowski, A.V., O'Donnell, A.F., Brodsky, J.L. Select a-arrestins control cell-surface abundance of the mammalian Kir2.1 potassium channel in a yeast model. The Journal of Biological Chemistry. 293 (28):11006-11021.
Christopher Szent-Gyorgyi, PhD (Carnegie Mellon University)
Position: Senior Research Scientist
Area of Study: Molecular, Structual, and Cellular Biology
Website: http://cmu.academia.edu/ChristopherSzentGyorgyi
Contact: css@cmu.edu
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Co-authored Papers:
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Hager, N.A., Kraswoski, C.J., Mackie, T.D., Kolb, A.R., Needham, P.G., Augustine, A.A., Dempsey, A., Szent-Gyorgyi, C., Bruchez, M.P., Bain, D.J., Kwiatkowski, A.V., O'Donnell, A.F., Brodsky, J.L. Select a-arrestins control cell-surface abundance of the mammalian Kir2.1 potassium channel in a yeast model. The Journal of Biological Chemistry. 293 (28):11006-11021.
Adam V. Kwiatkowski, PhD (University of Pittsburgh)
Position: Assistant Professor
Area of Study: Cardiomyocyte adhesion and cytoskeletal organization at the intercalated disc
Website: http://www.kwiatkowskilab.com/
Contact: adamkwi@pitt.edu
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Co-authored Papers:
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Hager, N.A., Kraswoski, C.J., Mackie, T.D., Kolb, A.R., Needham, P.G., Augustine, A.A., Dempsey, A., Szent-Gyorgyi, C., Bruchez, M.P., Bain, D.J., Kwiatkowski, A.V., O'Donnell, A.F., Brodsky, J.L. Select a-arrestins control cell-surface abundance of the mammalian Kir2.1 potassium channel in a yeast model. The Journal of Biological Chemistry. 293 (28):11006-11021.
Anne-Ruxandra Carvunis, PhD (University Pittsburgh)
Position: Assistant Professor
Area of Study: the molecular mechanisms of change and innovation in evolution of genomes over time
Website: http://www.csb.pitt.edu/faculty/carvunis/
Contact: anc201@pitt.edu
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Co-authored Papers:
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Vakirlis N., Acar O., Hsu B., Castilho Coelho N., Van Oss S.B., Wacholder A., Medetgul-Ernar K., Bowman R.W. 2nd, Hines C.P., Iannotta J., Parikh S.B., McLysaght A., Camacho C.J., O'Donnell A.F., Ideker T., Carvunis A.R. (2020) De novo emergence of adaptive membrane protein from thymine-rich genomic sequences. Nat Commun. Feb 7;11(1):781
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Jeremy Thorner, PhD (University of California, Berkeley)
Position: Professor of Biochemistry, Biophysics and Structural Biology
Area of Study: Transmembrane and intracellular signal transduction mechanisms
Website: http://mcb.berkeley.edu/labs/thorner/
Contact: jthorner@berkeley.edu
Co-authored Papers:
Prosser, D.C., A.E. Pannunzio, J.L. Brodsky, J. Thorner, B. Wendland, and A.F. O'Donnell. (2015) α-Arrestins participate in cargo selection for both clathrin-independent and clathrin-mediated endocytosis. The Journal of Cell Science 128 (22): 4220-4234.
O'Donnell, A.F., R. R. McCartney, D. G. Chandrashekarappa, B. Zhang, J. Thorner, and M.C. Schmidt. (2014) 2-Deoxyglucose impairs yeast growth by stimulating Snf1-regulated and α-arrestin-mediated trafficking of hexose transporters 1 and 3 in Saccharomyces cerevisiae. Molecular and Cellular Biology, 35(6):939-55.
C.G. Alvaro, A.F. O'Donnell*, D.C. Prosser, A.A. Augustine, A. Goldman, J. Brodsky, M.S. Cyert, B. Wendland, and J. Thorner. (2014) Specific α-arrestins negatively regulate Saccharomyces cerevisiae pheromone response by down-modulating the G-protein coupled recpetor Ste2. Molecular and Cellular Biology 34(14):2660-81.
*Co-first author
O'Donnell, A.F., L. Huang, J. Thorner, and M.S. Cyert. (2013) A calcineurin-dependent switch controls the trafficking function of α-arrestin Aly1/Art6. The Journal of Biological Chemistry. 288 (33): 24063-24080
Martha S. Cyert (Stanford University)
Position: Professor of Biology
Area of Study: Ca2+-dependent signal transduction, focusing on calcineurin
Website: http://web.stanford.edu/group/cyert/Home.html
Contact: MCYERT@stanford.edu
Papers co-authored with:
C.G. Alvaro, A.F. O'Donnell*, D.C. Prosser, A.A. Augustine, A. Goldman, J. Brodsky, M.S. Cyert, B. Wendland, and J. Thorner. (2014) Specific α-arrestins negatively regulate Saccharomyces cerevisiae pheromone response by down-modulating the G-protein coupled recpetor Ste2. Molecular and Cellular Biology 34(14):2660-81.
*Co-first author
O'Donnell, A.F., L. Huang, J. Thorner, and M.S. Cyert. (2013) A calcineurin-dependent switch controls the trafficking function of α-arrestin Aly1/Art6. The Journal of Biological Chemistry. 288 (33): 24063-24080
Minear, S., A.F. O'Donnell*, G. Giaever, C. Nislow, T. Stearns, and M.S. Cyert. (2011) Curcumin inhibits growth of Saccharomyces cerevisiae through iron chelation. Eukaryotic Cell 10 (11): 1574-81. *Co-first author
Piña, F.J., A.F. O'Donnell, S. Pagant, H.L. Piao, J.P. Miller, S. Fields, E.A. Miller, and M.S. Cyert. (2011) Hph1 and Hph2 are novel components of the Sec63/Sec62 posttranslational translocation complex that aid in vacuolar proton ATPase biogenesis. Eukaryotic Cell 10 (1): 63-71.
O'Donnell, A.F., A. Apffel, R.G. Gardner, and M.S. Cyert. (2010) α-arrestins Aly1 and Aly2 regulate intracellular trafficking in response to nutrient signaling. Molecular Biology of the Cell 21 (20): 3552-3566.
(Highlighted publication in MBoC)
